1. by car
Coming from Darmstadt:
Turn off the A67 motorway onto the A60 towards Mainz. Take the Mainz-Innenstadt exit and follow for the city centre.
Coming from Frankfurt:
Turn off the A3 motorway at the Mönchhofdreieck junction onto the A67. At the motorway junction Rüsselsheimer Dreieck turn onto the A60 and take the Mainz-Innenstadt exit towards the city centre
or alternatively
On the A66 motorway take the Wiesbaden-Mainzer Straße exit and follow for Mainz-Kastel. At Mainz-Kastel turn onto the B455 towards Mainz, entering the city via the Theoder-Heuss-Brücke across the Rhine.
Coming from Cologne:
Turn off the A3 motorway at the Wiesbadener Kreuz junction onto the A66 and follow for Wiesbaden. Turn off the A66 at Wiesbaden-Mainzer Straße and follow for Mainz-Kastel. At Mainz-Kastel turn onto the B455 towards Mainz, entering the city via the Theoder-Heuss-Brücke across the Rhine
or alternatively
Turn off the A61 motorway at the Dreieck Nahetal junction onto the A60, following for Mainz. Turn off the A60 at Mainz-Finthen and follow for Mainz-Innenstadt (city centre).
Coming from Kaiserslautern:Stay on the A63 motorway until you reach the city centre (Mainz-Innenstadt).
There are plenty of well-signposted car parks in the city centre ("Brand" & "Rahthaus"). The Gutenberg Museum can be easily reached on foot from any of them.
2. Public means of transport
Please use:
http://reiseauskunft.bahn.de/bin/query.exe
bus routes 54-57-60-65, and 71 from the central station to the Höfchen bus stop or
bus routes 64, 71 from the south central station ("Römisches Theater") to the Höfchen bus stop
Parking is available in the "Brand" and "Rathaus" multi-storey car parks (parking facilities for coaches on the Rhine banks).